There was no significant difference in PTH suppression. ![]() The mean serum calcium change was small and similar in the three groups. weekly vitamin D2 (12% difference in effect, P = 0.66) and daily D2 vs. Preplanned comparisons were nonsignificant: daily vitamin D2 vs. Infants received treatment for 6 wk.īefore and after treatment, serum measurements of 25(OH)D, PTH, calcium, and alkaline phosphatase were taken.Īll treatments approximately tripled the 25(OH)D concentration. Each was also prescribed elemental calcium (50 mg/kg.d). Participants were assigned to one of three regimens: 2,000 IU oral vitamin D2 daily, 50,000 IU vitamin D2 weekly, or 2,000 IU vitamin D3 daily. The study was conducted at an urban pediatric clinic in Boston.įorty otherwise healthy infants and toddlers with hypovitaminosis D participated in the study. This was a 6-wk randomized controlled trial. The objective of the study was to compare the safety and efficacy of vitamin D2 daily, vitamin D2 weekly, and vitamin D3 daily, combined with supplemental calcium, in raising serum 25-hydroxyvitamin D and lowering PTH concentrations. Hypovitaminosis D appears to be on the rise in young children, with implications for skeletal and overall health.
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